Key Pointers

  • Investing in NAD+ means decreased chances of aging poorly.
  • Reduced chances of weight gain, chronic diseases, and cancerous conditions.
  • Restore mitochondrial dysfunction and deregulated nutrient sensing.

Aging is a commonly understood process that is associated with a decrease in levels of NAD+. On average, from the age of 40 and onwards, the NAD+ starts declining. Using NAD+ boosters can have a tremendous effect on prolonging life. NAD+ boosters are the only supplements that work in internal process enhancement, the transport of energy for various metabolic pathways, gene repair, and DNA damage repair ensuring the effects of aging do not appear earlier.

NAD+ is well tolerated in higher doses. According to research, it can improve endurance, helps in preventing fat accumulation, and increase strength. NAD+ supplements can also assist in reversing age-related mitochondrial damage by increasing mitochondrial biogenesis. It also reduces the chances of developing age-related memory decline diseases such as Alzheimer’s and Parkinson’s disease by increasing neurogenesis and amyloid Beta production.

NAD+ has been shown to increase a healthy life span. Research study on animal models revealed that NAD+ supplements were able to improve glucose tolerance, insulin sensitivity, decreasing weight, and increase the rate of survival among rodents. The NAD+ supplements also help in resorting the skeletal muscle endurance through NAMPT and reduce chances of developing muscle wasting syndrome or Duchenne’s muscular dystrophy.

Using oral supplementation of NAD+ can increase the NAD+ level in humans. With limited research available on the human model, it was observed that NAD+ levels in white blood cells can rise to 60% through oral supplementations. According to a research study on 250 mg dosing of NAD+ in 120 adults with the age range of between 60-80 for four weeks, the NAD+ supplementation had a positive effect on liver functions by reducing alanine transaminase levels, and it can keep blood pressure within normal limits as well in the adult population.

NAD+ supplements can help reduce fatigue by increasing strength and endurance after the age of 40 or above. NAD+ is considered as one of the major components of metabolic pathways known as the Krebs cycle to produce electron carriers for cellular respiration at later stages. NAD+ supplements improved the mitochondrial energy levels in cardiac and other skeletal muscles leading to increase energy by the production of ATP.

Investing in NAD+ supplements means a healthier digestive system. However, it is important to maintain a healthy diet and lifestyle along with supplementation to ensure the doubled positive impact of NAD+ supplements on cellular metabolism. NAD+ level can be lower due to diet-induced obesity. Oral supplementation can rapidly prevent weight gain due to diet by increasing the levels of SIRT1 and NAD+ levels. The higher production of sirtuins proteins has been associated with slowing the process of aging, that is one of the reasons why NAD+ supplements are also known as anti-aging supplements.


NAD+ supplements are worth investing in from an early age to get a head of the negative aging cycle before it even begins, allowing for the negative aging cycle to be put on hold, by the age of 40 and above NAD+ is an essential health investment as the increased chances of disease and age related decline begins to rapidly increase. It helps to maintain weight, strength, and fitness. It reduces the chances of developing age-related memory diseases and chronic diseases such as hypertension and diabetes. NAD+ is an extremely safe supplement with no harmful evidence documented.


  1. Dellinger, Ryan W., et al. "Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study." npj Aging and Mechanisms of Disease 3.1 (2017): 1-9.
  2. Airhart, Sophia E., et al. "An open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers." PloS one 12.12 (2017): e0186459.
  3. Aman, Yahyah, et al. "Therapeutic potential of boosting NAD+ in aging and age-related diseases." Translational Medicine of Aging 2 (2018): 30-37.
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