Key Pointers

NAD+ plays important role in anxiety as :

  • The natural chemistry of the brain is responsible for regulating mood, which can be restored with NAD+.
  • Your body naturally produces NAD (nicotinamide adenine dinucleotide) from niacin.
  • Anxiety symptoms may be improved by NAD+.

Human biochemical reactions designed to protect against perceived danger, stress, and anxiety are innately ingrained as protective mechanisms. If you're wrestling with an alligator or running from a grizzly, exercise and a heightened sense of awareness come in handy. Nevertheless, once the danger has passed, the body's chemical elements will revert to their original state.

The brain's chemistry is altered when someone is stressed, anxious, depressed, or suffering other illnesses. The natural chemistry of the brain is responsible for regulating mood, which can be restored with increased NAD+ availability. A wide variety of roles are played by NAD+ in all our cells. In essence, NAD+ is a key component of our cells' ability to create energy.

Your body naturally produces NAD (nicotinamide adenine dinucleotide) from niacin. By leading to the regeneration of your brain's neurotransmitters, this coenzyme reverses mitochondrial damage. A growing number of people are being treated with NAD for anxiety disorders due to its effectiveness and safety. Increased NAD+ can reduce depression and anxiety, as well as support your mood. Early studies of NAD have shown promising results, though the potential of this compound remains to be explored. This study describes how NAD supplementation may help manage anxiety and depression, as fatigue is a characteristic of both conditions.

In addition to cell health and neurological function, mitochondrial dysfunction can cause several disorders. There has been evidence that mitochondrial damage can result in cognitive changes along with anxiety and depression. Study results suggest that NAD will improve neural changes by improving mitochondrial function. NAD restoration may restore mitochondrial function and make your brain and body function better. As mitochondrial function improves, energy is being restored. The brain uses this energy and performs its major function. As we know energy is being used to synthesize and release neurotransmitters. These neurotransmitters improve brain activity, so anxiety symptoms may be improved by increased amounts of NAD+. The body naturally produces this coenzyme. Throughout the body, the NAD+ performs several functions, including:

  • Assisting mitochondria to heal themselves
  • Due to the elimination of free radicals that potentially cause cellular damage'
  • Reduction of inflammation
  • Boosting cellular metabolism
  • Improving cellular functioning

The brain is also regulated by NAD+. Neurotransmitters are transmitted, to ensure that signals move between nerve endings.

The coenzyme called NAD+ plays a role in the production of energy. By maintaining cellular health, NAD+ helps to maintain a feeling of well-being. Increased NAD+ can work to improve your symptoms of anxiety by correcting imbalances in this coenzyme.


Anxiety is a state of mind in which the Brain is unable to maintain emotions because of an imbalance of neurotransmitters and energy loss. NAD+  relieves anxiety symptoms by producing energy and maintain proper neurotransmitter balance in the brain. NAD+ also helps in maintaining mitochondrial function.


  1. Lopatina, O. et al. anxiety- and depression-like behavior in mice lacking the CD157/BST1 gene, a risk factor for Parkinson’s disease. Front. Behav. Neurosci. 8, 133 (2014).
  2. Alegre J, Rosés JM, Javierre C, Ruiz-Baqués A, Segundo MJ, de Sevilla TF. Nicotinamida adenina dinucleótido (NADH) en pacientes con síndrome de fatiga crónica [Nicotinamide adenine dinucleotide (NADH) in patients with chronic fatigue syndrome]. Rev Clin Esp. 2010 Jun;210(6):284-8. Spanish. doi: 10.1016/j.rce.2009.09.015. Epub 2010 May 5. PMID: 20447621.
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